Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1990-07-06
1993-08-31
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4351723, 935 10, 935 14, 424 9464, C12N 970, C12N 1500, A61K 37547
Patent
active
052408450
ABSTRACT:
This invention relates to a novel chemically synthesized gene including a base sequence coding for the primary amino acid sequence of natutal-type streptokinase, a corresponding plasmid recombinant, corresponding transformant and process for preparing streptokinase by the incubation of the transformant, the invention further relating to novel streptokinase derivative proteins having streptokinase activity and a modified primary amino acid sequence corresponding to the primary amino acid sequence of natural-type streptokinase which is deficient in the amino acid residues at the 373-position to the C-terminus, and wherein at least one of the amino acid residues may be deficient, replaced or inserted; the chemically synthesized gene including a base sequence coding for the derivative protein, plasmid containing the gene, transformant transformed by the plasmid, and process for preparing the streptokinase derivative protein by the incubation of the transformant.
REFERENCES:
Rajagopalan, et al., J. Clin. Invest., vol. 75, Feb. 1985, pp. 413-419.
Jackson, et al., Biochemistry, vol. 25, No. 1, 1986, pp. 108-114.
Koide, et al., FEBS Letters, vol. 143, No. 1, Jun. 1982, pp. 73-76.
Jackson, et al., Biochemistry, vol. 21, No. 26, 1982, pp. 6620-6625.
Fujii, deceased Setsuro
Katano Tamiki
Majima Eiji
Ogino Koichi
Ono Kenji
Hendricks Keith D.
Otsuka Pharmaceutical Factory, Ltd.
Wax Robert A.
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