Method of manufacturing a test article for the determination of

Details Method of manufacturing a test article for the determination of Method of manufacturing a test article for the determination of

1991-07-01

1993-08-31

Housel, James C.

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

422 56, 422 57, 436 86, 436 87, 436 88, 436166, 436169, 436 66, 436 67, 437 8, G01N 2178, G01N 3368

Patent

active

052407357

ABSTRACT:
A method of manufacturing a test device for determining the presence and concentration of proteins, such as albumin or Bence Jones proteins, in a test sample. The test device includes a carrier matrix incorporating a reactant system capable of interacting with proteins to produce a visually or instrumentally detectable and/or measurable response. The carrier matrix of the device can include commonly used bibulous matrices, such as filter paper, or a nonbibulous protein-permeable strip, membrane or layer of a polymerized urethane-containing composition. In addition, a reactant system, including a dual indicator reagent system, such as bromophenol blue, methyl orange and, if necessary, a suitable buffer, is incorporated into the carrier matrix to provide improved color resolution and increased sensitivity to proteins, thereby affording a more accurate and trustworthy protein assay of test samples, such as urine. Furthermore, by incorporating the dual indicator reagent system into a carrier matrix including a polymerized urethane-containing composition, a dry phase assay for low molecular weight proteins, such as Bence Jones proteins, can be performed on a liquid test sample.

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patent: 4689309 (1987-08-01), Jones
patent: 4786605 (1988-11-01), Mauck et al.
patent: 5096833 (1992-03-01), Lau et al.
patent: 5124266 (1992-06-01), Coryn et al.

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