Transdermal therapeutic system comprising as active component bu

Details Transdermal therapeutic system comprising as active component bu Transdermal therapeutic system comprising as active component bu

1992-09-24

1993-08-31

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

401449, 401441, 401443, A61F 1302

Patent

active

052407110

ABSTRACT:
The controlled release of buprenorphine or the pharmaceutically acceptable salts thereof to the skin over a period of time of at least 24 hours is ensured by a transdermal therapeutic system consisting of a backing layer which is impermeable to the active substance, a pressure-sensitive adhesive reservoir layer, and optionally a removable protective layer. Said reservoir layer of said system comprises 20 to 90%-wt polymeric material, 0.1 to 30%-wt softener, 0.1 to 20%-wt buprenorphine base or one of the pharmaceutically acceptable salts thereof, and 0.1 to 30%-wt solvent for the active substance base.

REFERENCES:
patent: 4806341 (1989-02-01), Chien et al.
patent: 4911916 (1990-03-01), Cleary
patent: 4915950 (1990-04-01), Miranda et al.
patent: 4983395 (1991-01-01), Chang et al.

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