Dihydrochalcone derivatives which are hypoglycemic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 23, 514866, 536 41, A61K 3170

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active

057312923

ABSTRACT:
A method for prophylaxis or treatment of diabetes, which comprises administering to a patient with diabetes an effective amount of a ##STR1## wherein Ar is an aryl group, R.sup.1 is hydrogen atom or an acyl group, R.sup.2 is a hydrogen atom, an acyl group or .alpha.-D-glucopyranosyl group, or R.sup.1 and R.sup.2 may combine together to form a substituted methylene group, R.sup.3 and R.sup.4 are each a hydrogen atom or an acyl group, OR.sup.5 is a protected or unprotected hydroxy group or a lower alkoxy group, or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3984394 (1976-10-01), Westall et al.
patent: 4031260 (1977-06-01), Westall et al.
patent: 4665058 (1987-05-01), Deidrich et al.
patent: 4684627 (1987-08-01), LeVeen et al.
patent: 4760135 (1988-07-01), Diedrich et al.
patent: 4840939 (1989-06-01), LeVeen et al.
patent: 5110801 (1992-05-01), LeVeen et al.
patent: 5424406 (1995-06-01), Tsujihara et al.
D. Diedrich (1963) Biochim. Biophys. Acta, (71) 688-700.
Rosetti et al. (1990) Diabetes Care 13(6), 610-630.
Rosetti et al. (1987) J. Clin. Invest. (79) 1510-1515.
Rosetti et al. (1987) J. Clin. Invest. (80) 1037-1044.
Kahn et al. (1991) J. Clin. Invest (87) 561-570.
Unger et al. (1985) Diabetologia 28:119-121.
Olendorf et al. (1983) Stroke (14) 388-393.
Winget et al. (1969) Biochemistry (8) 2067-2074.
Vick et al. (1973) Am. Journal of Physiology 224 (3) 552-557.
D. Diedrich (1966) Ar. of Biochem. and Biophy. 117:248-256.
Evans et al. (1980) Ar. of Biochem. and Biophy. 199(2) 342-348.
Bode et al. (1972) Biochim. Biophys. Acta, 290 134-149.
Pzabo et al., Acta Alimentaria, vol. 11 (1), pp. 31-37.
Unger et al., Diabetologia, 28 (1985), 119-121.
"Guidelines for Toxicity Studies of Drugs," Ministry of Health and Welfare of Japan, 114-118.
Fujiwara et al., Diabetes, (37) (1988) 1549-1558.
Dorland's Medical Dictionary, 27 ed., pp. 460-461 (1988).
Odaka et al., J. Nutr. Sci. Vitaminol, 38 (1992) Abstract.

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