Recombinant adenovirus and process for producing the same

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4351723, 4353201, 435369, C12N 1564, C12N 1566

Patent

active

057311722

ABSTRACT:
Disclosed are a recombinant adenovirus bearing a DNA sequence encoding a desired foreign polypeptide, and a hybrid promoter (CAG promoter) comprising a cytomegalovirus enhancer, a chicken .beta.-actin promoter, a rabbit .beta.-globin splicing acceptor and a polyA sequence, a process for production thereof, as well as use thereof for in genetic treatment. The recombinant adenovirus effectively expresses the foreign polypeptide in a wide range of animal cells.

REFERENCES:
Saito, et al "Construction of Nondefective Adenovirus Type 5 Bearing a 2.8 Kilobase Hepatitis B Virus DNA . . . ," Journal of Virology, vol. 54, No. 3, pp. 711-719, Jun. 1985.
Sharp, et al "The Infectivity of Adenovirus 5 DNA-Protein Complex," Virology, 75, 442-456 (1976).
Gu et al., "Deletion of DNA Polymerase . . . Targeting," Science, vol. 265, Jul. 1, 1994, pp. 103-106.
Anton et al., "Site Specific Recombination Mediated . . . Expression," Journal of Virology, Aug. 1995, pp. 4600-4606.
First Annual Meeting 1995 Japanese Society of Gene Therapy, Program and Abstract, May 21, 1995, Kanagae et al, "Application of Cre/LoxP System to Adenovirus Vector".
Kanegae et al., "Efficient Gene Activation . . . Recombinase," Nucleic Acids Research, vol. 23, No. 19, pp. 3816-3821 (1995).
Bergemann et al., "Excision of Specific DNA . . . Recombination," Nucleic Acids Research, vol. 23, No. 21, pp. 4451-4456 (1995).
The 43rd Annual Meeting of the Society of Japanese Virologists, (Sep. 29, 1995), 2016, p. 126.
The Second Brain Tumor Gene Therapy Meeting, Feb. 3 and 4, 1995, "Adenovirus Vector".
Ghosh-Choudhury et al., "Protein IX, A Minor Component of the Human Adenovirus Capsid, is Essential for the Packaging of Full Length Genomes", EMBO J., vol. 6, No. 6, pp. 1733-1739, 1987.
K.L. Berkner, "Expression of Heterologous Sequences in Adenoviral Vectors", Current Topics in Microbiol. and Immunol., vol. 158 1992, pp. 39-66.
Saito et al., "Adenovirus Vector", The 41.sup.st General Meeting: The Society of Japanese Virologists (1993).
Kanegae et al., "Adenovirus Vector and Gene Therapy", Experimental Medicine, vol. 12, No. 3 (1994).
Kanegae et al., Experimental Medicine Supplemental Volume, Biomanual Series 4, pp. 43-58 (1994).
Niwa et al, "Efficient Selection for High-Expression Transfectants with a Novel Eukaryotic Vector," Gene, 108, pp. 193-200 (1991).
Engelhardt et al, "Direct Gene Transfer of Human CFTR Into Human Bronchial Epithelia of Xenografts with El-Deleted Adenoviruses," Nature Genetics, vol. 4, pp. 27-34 (May 1993).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Recombinant adenovirus and process for producing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant adenovirus and process for producing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant adenovirus and process for producing the same will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2288001

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.