Induction of antigen specific T-lymphocyte responses by stimulat

Details Induction of antigen specific T-lymphocyte responses by stimulat Induction of antigen specific T-lymphocyte responses by stimulat

1992-05-26

1998-03-24

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435352, 435355, 435366, 435375, 435377, 436501, 4241841, 424 9371, 424534, G01N 33554, C12N 506, A61K 4505

Patent

active

057311609

ABSTRACT:
Induction of an antigen-specific T-lymphocyte response in a T-lymphocyte culture, e.g. a primary cytotoxic T-lymphocyte (CTL) response, by loading antigen-presenting vehicles which carry empty MHC molecules with an antigen-derived T-cell-immunogenic MHC-binding peptide, culturing T-lymphocytes in the presence of the peptide-loaded antigen-presenting vehicles under specific T-lymphocyte response-inducing conditions. Optionally, an antigen-specific T-lymphocyte is isolated from the resulting culture and cultured. The process can be used for preparing CTL which are specific for viral or other foreign antigens, or CTL which are specific for autologous peptides. The process can also be used for the identification of peptides that are capable of binding to MHC and inducing a T cell response.

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