High affinity TGF.beta. nucleic acid ligands

Details High affinity TGF.beta. nucleic acid ligands High affinity TGF.beta. nucleic acid ligands

1995-06-02

1998-03-24

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 254, C12P 1934, C12Q 168, C07H 2104, C07H 2102

Patent

active

057311447

ABSTRACT:
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF.beta.. Included in the invention are specific RNA and ssDNA ligands to TGF.beta.1 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF.beta.1 with its receptor.

REFERENCES:
patent: 5270163 (1993-12-01), Gold et al.
patent: 5459015 (1995-10-01), Janjic et al.
Arteaga et al. (1993) J. Clin. Invest. 92:2569.
Arteaga et al. (1990) Cell Growth & Differentiation 1:367.
Barral et al. (1993) Proc. Natl. Acad. Sci. USA 90:3442.
Shah et al. (1992) Lancet 339:213.
Joyce (1989) Gene 82:83.
Joyce and Inoue (1989) Nucleic Acids Research 17:711.
Ellington and Szostak (1990) Abstract of papers presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 226.
Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn and Spiegelman (1969) Proc. Natl. Acad. Sci. USA 63:805.
Levisohn and Spiegelman (1968) Proc. Natl. Acad. Sci. USA 60:866.
Oliphant et al. (1989) Mol. Cell. Biol. 9:2944.
Oliphant and Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant and Struhl (1987) Methods in Enzymology 155:568.
Oliphant et al. (1986) Gene 44:177.
Robertson and Joyce (1990) Nature 344:467.
Thiesen and Bach (1990) Nucleic Acids Research 18:3203.

Affiliated with

Also associated with

Rating

High affinity TGF.beta. nucleic acid ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High affinity TGF.beta. nucleic acid ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High affinity TGF.beta. nucleic acid ligands will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2287830