Pharmaceutical compositions containing azanaphthalene-carboxamid

Details Pharmaceutical compositions containing azanaphthalene-carboxamid Pharmaceutical compositions containing azanaphthalene-carboxamid

1983-12-22

1987-12-08

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 540597, 540600, 544116, 544128, 544284, 544283, 546167, 546169, A61K 3147, C07D21522

Patent

active

047118903

ABSTRACT:
Compounds of the formula: ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, phenyl, C.sub.3-6 cycloalkyl, phenylalkyl, cycloalkyl-alkyl or ##STR2## R.sub.3 and R.sub.4 being H or alkyl, R.sub.5 being alkenyl or alkynyl, and the sum of the carbon atoms in R.sub.3, R.sub.4 and R.sub.5 being 2 to 5, R.sub.2 is as defined for R.sub.1 and may also represent ##STR3## in which n is 0, 1, 2 or 3, it also being possible for R.sub.1 and R.sub.2 to form, with the nitrogen atom to which they are attached, a 5-, 6- or 7-membered heterocyclic radical which can contain another hetero-atom chosen from O and N and which can carry 1 or 2 substituents, Z is phenyl, pyridinyl, thienyl, thiazol-2-yl or substituted phenyl, X and R.sub.0 are H, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, nitro or CF.sub.3, A represents N or CH and E represents N or CH, some of which are known compounds, are therapeutically useful compounds useful in the treatment of anxiety states or of pulmonary, renal, circulatory or cardiovascular disorders.

REFERENCES:
patent: 4499094 (1985-02-01), Dubroeucq et al.
Roushdi, et al., "Chemical Abstracts", vol. 58, 1963, col. 13912e.
Pagani, et al., "Chemical Abstracts", vol. 82, 1975, col. 27089r.
DeWit, et al., "J. Org. Chem.", vol. 46, 1981, pp. 172-175.

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