Method for the iontophoretic administration of bisphosphonates

Details Method for the iontophoretic administration of bisphosphonates Method for the iontophoretic administration of bisphosphonates

1996-06-14

1998-03-24

Bockelman, Mark

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

604 49, 607 51, A61N 130

Patent

active

057307156

ABSTRACT:
A method for preventing the onset or advancement of osteoporosis or other metabolic bone disorders in a patient by iontophoretically administering to the patient an effective amount of a bisphosphonate which would be effective for preventing the onset or advancement of osteoporosis or other bone disorders and wherein the effective amount of bisphosphonate is delivered over a period of from about four (4) hours to about forty-eight (48) hours, at intervals of from about once a week to about twice a year and wherein the effective amount of bisphosphonate also contains an agent capable of chelating calcium.

REFERENCES:
patent: 4822609 (1989-04-01), Flora
patent: 5376107 (1994-12-01), Inagi et al.
Landman, J.O, et al, "Recovery of Serum Calcium Concentrations Following Acute Hypocalcemia in Patients with Oskoporosis . . . " J. Clin. Endocrin. Met. 80(2)524-8(1995).
Dawson-Hughes, B. et al., "A Controlled Trial of the Effect of Calcium Supplementation on Bone Density . . . " New England J. of Medicine, Sep. 27, 1990 323(13) 878-883.
Watts, N.B., Blevins, L.S. Jr., "Endocrinology" JAMA Jun. 19, 1996 275(23) 1806-07.
Pak, C.Y.C. et al, "Treatment of Postmenopausal Osteoporosis with Slow Release Sodium Fluoride," Annals of Internal Medicine, Sep. 15, 1995, 123(6) 401-08.
Storm, Tommy, et al. Effect of Intermittent Cyclical Etidronate Therapy on Bone Mass and Fracture Rate in Women with Postmenopausal Osteoporosis, 322 New England Jnl of Med. 1265 (1990).

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