Prodrugs of carbonic anhydrase inhibitors

Details Prodrugs of carbonic anhydrase inhibitors Prodrugs of carbonic anhydrase inhibitors

1989-09-22

1992-03-10

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

536 41, 536 11, 514913, 514 54, 514363, 514603, 514604, A61K 31425

Patent

active

050950266

ABSTRACT:
Prodrugs are prepared of the carbonic anhydrase inhibitors 2-benzothiazolesulfonamide, hydroxymethazolamide, and dichlorphenamide. The prodrugs link a water soluble compound to the pharmacologically active carbonic anhydrase inhibitor through an enzymatically or hydrolytically degradable bond.

REFERENCES:
patent: 4386098 (1983-05-01), Woltersdorf, Jr. et al.
patent: 4483864 (1984-11-01), Barfknecht et al.
patent: 4483872 (1984-11-01), Barfknecht et al.
patent: 4499103 (1985-02-01), de Solms
patent: 4505923 (1985-03-01), Hoffman, Jr. et al.
patent: 4510155 (1985-04-01), Smith et al.
patent: 4629738 (1986-12-01), Barfknecht et al.
patent: 4636515 (1987-01-01), Barfknecht et al.
patent: 4861760 (1989-08-01), Mazuel et al.
Larsen et al., "Prodrug Forms for the Sulfonamide Group", Acta Pharm. Nordica 1, 31 (1989).
Bundgaard et al., "N-Sulfonyl Imidates as a Novel Prodrug Form for an Ester Function or a Sulfonamide Group", J. Med. Chem, 31, 2066 (1988).

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