Piperidine derivatives and pharmaceutical compositions comprisin

Details Piperidine derivatives and pharmaceutical compositions comprisin Piperidine derivatives and pharmaceutical compositions comprisin

1990-06-13

1992-03-10

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514325, 546196, 546203, A61K 31445, C07D40304

Patent

active

050950223

ABSTRACT:
A piperidine derivative represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or a lower alkyl group; X represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, or --CH.sub.2 O--; Y represents an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represented an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

REFERENCES:
patent: 3470188 (1969-09-01), Kaiser et al.
patent: 4826853 (1989-05-01), Piwinski et al.

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