Certain azacycloalkyl imidazopyrimidines; a new class of GABA br

Details Certain azacycloalkyl imidazopyrimidines; a new class of GABA br Certain azacycloalkyl imidazopyrimidines; a new class of GABA br

1990-07-24

1992-03-10

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514267, 540521, 540578, 544251, A61K 3155, A61K 31505, C07D51500, C07D23900

Patent

active

050950150

ABSTRACT:
The invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof where n is 0, 1, or 2 and x is ##STR2## and R.sub.1, R.sub.2, R.sub.3, Y, Z, W, T are defined variables. These compounds are highly selective agonists or inverse agonists for the GABAa brain receptors and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine type drugs, and enhancement of alertness.

REFERENCES:
patent: 4643999 (1987-02-01), Tully
patent: 4713383 (1987-12-01), Francis et al.
patent: 4831013 (1989-05-01), Francis

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