Cytotoxic antibody conjugates of hydrazide derivatized vinca ana

Details Cytotoxic antibody conjugates of hydrazide derivatized vinca ana Cytotoxic antibody conjugates of hydrazide derivatized vinca ana

1991-01-14

1992-03-10

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

5303919, 530408, 530409, A61K 3944, C07K 1702

Patent

active

050948490

ABSTRACT:
A series of antibody-vinca drug conjugates comprise antibodies which target antigens associated with undesirable cells, so that the cells are controlled or killed by the cytotoxic vinca drug. The drug is linked to the antibody through an organic group comprising a carbonyl at the antibody end, and an alkylidene hydrazide at the vinca end.

REFERENCES:
patent: 4203898 (1980-05-01), Cullinan et al.
patent: 4631190 (1986-12-01), Shen et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4675400 (1987-06-01), Cullinan
patent: 4801688 (1989-01-01), Laguzza et al.
patent: 4828831 (1989-05-01), Hannart et al.
Blickenstaff, et al., Chemical Abstracts, vol. 94: 114277s (1981).
King et al., Biochem. 25, 5774-79 (1986).
Ghose et al., Methods Enzymology 93, 280-333 (1983).
Blair et al., J. Immunol. Methods 59, 129-43 (1983).
Shen et al., Biochem. Biophys. Res. Comm. 102, 1048-54 (1981).
Bumol et al., AACR Proceedings, Abstract 1410 (1984).
Bumol et al., J. Cell Biochem., Supp. 9A, Abstract 0124 (1985).
Ghose et al., CRC Critical Rev. in Therapeutic Drug Carrier Systems 3, 263-359 (1987).
Bumol et al., Faseb 69th Annual Meeting, Abstract 8484 (1985).

Affiliated with

Also associated with

Rating

Cytotoxic antibody conjugates of hydrazide derivatized vinca ana does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cytotoxic antibody conjugates of hydrazide derivatized vinca ana, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytotoxic antibody conjugates of hydrazide derivatized vinca ana will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2283499