Fluorescence-based optical sensor and method for detection of li

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample

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128634, 25022714, 2504591, 2504831, 422 56, 422 57, 422 58, 422 8202, 422 8211, 436126, 436132, 436169, 436172, 436178, G01N 2164

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050948199

ABSTRACT:
A sensor, probe, system and method for detecting the presence of or concentration of lipid-soluble analytes such as anesthetics, which involve the use of fluorophore-containing lipid layers or similar amphiphilic structures as the sensor. The lipid layer is constituted such that it has a phase transition temperature equal to or close to the temperature at which the measurement of the analyte is conducted. Partitioning of a suitable analyte into the lipid layer results in a phase change which is then reflected in a change in a fluorescence characteristic, such as a shift in the wavelength of maximum intensity of fluorescence, of the fluorophore, in proportion to the amount of analyte.

REFERENCES:
patent: 4255053 (1981-03-01), Lubbers et al.
patent: 4306877 (1981-12-01), Lubbers
patent: 4682895 (1987-07-01), Costello
patent: 4929561 (1990-05-01), Hirschfeld

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