Retinoid compounds

Details Retinoid compounds Retinoid compounds

1990-06-29

1992-03-10

Dees, Jose G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

562510, 568827, C11C 100

Patent

active

050947834

ABSTRACT:
Retinoid compounds with bioactive properties and their synthesis are described. The compounds are useful as chemopreventive or cancer-treating agents and dermatological agents. The novel retinoids are members of either of the two general structures: ##STR1## wherein X is CO.sub.2 H or CH.sub.2 OH; and in formula (I), R.sub.1 and R.sub.2 are each hydrogen, a C.sub.1-4 alkyl, a C.sub.1-4 alkoxy, or R.sub.1 and R.sub.2 taken together form a 5- to 7-membered cycloalkyl or cycloalkenyl ring; and in formula (II), R.sub.1 and R.sub.2 are each hydrogen, a C.sub.1-4 alkyl, a C.sub.1-4 alkenyl or a C.sub.1-4 alkoxy, or R.sub.2 and R.sub.3 taken together form a 5- to 7-membered cycloalkyl or cycloalkenyl with R.sub.1 and R.sub.4 being a hydrogen atom, a C.sub.1-4 alkyl, a C.sub.1-4 alkenyl or a C.sub.1-4 alkoxy.

REFERENCES:
Robinson et al., "Reactions of Vinylogous Phosphonate Carbanions and Reformatsky Reagents with a Sterically Hindered Ketone and Enone", Journal of Organic Chemistry, vol. 54, May, 1989, 1992-1997.

Affiliated with

Also associated with

Rating

Retinoid compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Retinoid compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Retinoid compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2283111