Dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives, process f

Details Dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives, process f Dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives, process f

1979-02-21

1980-12-09

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424275, 424278, 260333, C07D31314, C07D33714

Patent

active

042386209

ABSTRACT:
Novel dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives of the formula ##STR1## wherein X is an oxygen or sulfur atom, each of R.sub.1 and R.sub.2 is a hydrogen atom or a methyl group, and R.sub.3 is a hydrogen atom or a 2-(2-hydroxyethoxy)ethyl group; provided that when R.sub.1 is a hydrogen atom, the group ##STR2## is a group other than a 1-carboxyethyl group; and when X is a sulfur atom, both R.sub.1 and R.sub.2 are methyl groups;
and pharmaceutically acceptable salts of said compounds in which R.sub.3 is a hydrogen atom. Compositions of said compounds, processes for the preparation of said compounds, and a method of using said compounds are also provided. These novel compounds have excellent anti-inflammatory, analgesic and antipyretic activities.

REFERENCES:
patent: 4104280 (1978-08-01), Ackrell
Ackrell et al., J. Med. Chem., vol. 21, pp. 1035-1044 (1978).

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