Crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate

Details Crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate Crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate

1986-09-08

1987-12-08

Evans, J. E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

2605025C, A61K 31045, A61K 3166, C07F 938

Patent

active

047118806

ABSTRACT:
The invention relates to a novel crystal modification, containing water of crystallization, of disodium 3-amino-1-hydroxypropane-1,1-diphosphonate of the formula ##STR1## and to a process for the manufacture thereof. This modification is suitable for the oral treatment of disorders of the calcium and phosphate metabolism and associated diseases in warm-blooded animals.

REFERENCES:
patent: 3962432 (1976-06-01), Schmidt-Dunker
patent: 4054598 (1977-10-01), Blum et al.
patent: 4086334 (1978-04-01), Schmidt-Dunker et al.
patent: 4134969 (1979-01-01), Schmidt-Dunker
patent: 4304734 (1981-12-01), Jary et al.
patent: 4327039 (1982-04-01), Blum et al.
patent: 4407761 (1983-10-01), Blum et al.
patent: 4446052 (1984-05-01), Sunberg et al.
Chem. Abstr. 78:84528Z.

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