Process for preparation of N-demethyl-4"-deoxy-erthromycins A an

Details Process for preparation of N-demethyl-4"-deoxy-erthromycins A an Process for preparation of N-demethyl-4"-deoxy-erthromycins A an

1996-11-22

1999-07-13

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 185, C07H 100

Patent

active

059228490

ABSTRACT:
A process for the preparation of N-demethyl-4"-deoxy-erythromycins A and B, having the formula: ##STR1## wherein R.sup.a is H or OH, by stepwise addition of iodine and base to the N-dimethyl-4"-deoxyerythromycin, preferably, accompanied by sparging with an inert gas.

REFERENCES:
patent: 3725385 (1973-04-01), Freiberg
Synthesis of 4"-Deoxy Motilides: Identification of a Potent and Orally Active Prokinetic Drug Candidate, P. Lartey et al., Journal of Medicinal Chemistry, vol. 38, No. 10, pp. 1793-1798 (1995).

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