Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-07-14
1999-07-13
LeGuyader, John L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C07K 100
Patent
active
059228440
ABSTRACT:
The present invention provides a polynucleotide (ipka) which identifies and encodes a novel human cAMP-dependent protein kinase A inhibitor homolog (IPKA). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding IPKA. The invention also provides for the use of purified IPKA and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of IPKA. Additionally, the invention provides for the use of antisense molecules to ipka in pharmaceutical compositions for treatment of diseases associated with the expression of IPKA. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ipka. The present invention also relates to anti-IPKA antibodies which specifically bind to IPKA.
REFERENCES:
Hillier, L et al., (GI 1273286) GenBank Sequence Database (Accession W01305), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Hillier, L et al., (GI 1060256) GenBank Sequence Database (Accession H82167), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Gamm, DM and Uhlers, MD, "Isoform-specific Differences in the Potencies of Murine Protein Kinase Inhibitors Are Due to Nonconserved Amino-terminal Residues" The Journal of Biological Chemistry 270 (13):7227-7232 (1995).
Fantozzi, DA et al., "Thermostable Inhibitor of cAMP-dependent Protein Kinase Enhances the Rate of Export of the Kinase Catalytic Subunit from the Nucleus" The Journal of Biological Chemistry 269(4):2676-2686 (1994).
Wen, W et al., "The Expression and Intracellular Distribution of the Heat-stable Protein Kinase Inhibitor Is Cell Cycle Regulated" The Journal of Biological Chemistry 270(5):2041-2046 (1995).
Baude et al., Evidence for the Importance of Hydrophobic Residues in the Interactions between the cAMP-dependent Protein Kinase Catalytic Subunit and the Protein Kinase Inhibitors, J. Biol. Chem., 269:18128-18133.
Drumm et al., Molecular Biology of Cystic Fibrosis, Mol. Genet Med., 3:33-68.
Marchetto et al., Cloning and sequencing of the cDNA encoding the avian kidney cAMP-dependent protein kinase inhibitor protein, Gene, 158:303-304.
Wang et al., Specific Processing of Native and Phosphorylated .tau. Protein by Proteases, J. Biol. Chem., 270:2041-2046.
Wen et al., The Expression and Intracellular Distribution of the Heat-stable Protein Kinase Inhibitor Is Cell Cycle Regulated, J. Biol. Chem., 270(5):2041-2046.
Olsen, S.R., et al. "Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinases" J. Biol. Chem., 266(17):11158-11162.
Au-Young Janice
Hawkins Phillip R.
Hillman Jennifer L.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
LeGuyader John L.
Mohan-Peterson Sheela
Wang Andrew
LandOfFree
Human cAMP-dependent protein kinase inhibitor homolog does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human cAMP-dependent protein kinase inhibitor homolog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human cAMP-dependent protein kinase inhibitor homolog will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2276527