PEA3 is a tumor suppressor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 2, 4353201, 435975, A61K 3800, A61K 4800, C12N 1500

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059226889

ABSTRACT:
The present invention relates generally to the fields of cancer therapy and gene therapy. More particularly, it demonstrates that PEA3 is a tumor suppressor and may be used to treat various forms of cancer, and especially neu-mediated cancer.

REFERENCES:
patent: 5773743 (1998-07-01), Frisch
Gutman and Wasylyk, "Nuclear targets for transcription regulation by oncogenes," TIG, 7:49-54, 1991.
International Search Report dated Jul. 8, 1998 (PCT/US98/00880)(UTFC:500P).
Wasylyk et al., "The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation," Nature, 346:191-193, 1990.
Chang et al., "ETS and OB2-1 factors mediate transcriptional overexpresion of HER2
eu", Proceedings of the American Association for Cancer Research 36:532, Abstract #3167, 1995.
Galang, et al., "Oncogenic Neu/Erb-B-2 Increases Ets, AP-1, and NF-.kappa.B-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation", The Journal of Biological Chemistry 271:(14) 7992-7998, 1996.
Higashino, et al., Isolation of a cDNA encoding the adenovirus EIA enhancer binding protein: a new human member of the ets oncogene family, Nucleic Acids Research 21:(3) 547-553, 1993.
Higashino, et al., "Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters", Oncogene 10:1461-1463, 1995.
Isobe, et al., "Assignment of the ets-Related Transcription Factor E1A-F Gene (ETV4) to Human Chromosome Region 17q21", Genomics 28:357-359, 1995.
Macleod, et al., "The ets gene family", TIBS 17:251-256, 1992.
O'Hagan, et al., Activation of HER2
eu kinase induces overexpression of the Ets-related transcription factor PEA3, Proceedings of the American Association for Cancer Research 37:522, Abstract #3575, 1996.
Scott, et al., An ets related transcription factor contributes to HER2
eu overexpression in human breast cancer cells, Proceedings of the American Association for Cancer Research 34:529, Abstract #3158, 1993.
Scott, et al., "ETS-related transcription factors isolated from HER2
eu overexpressing breast cancer cells", Proceedings of the American Association for Cancer Research 35:598, Abstract #3563, 1994.
Scott, et al., "Binding of an ETS-related Protein within the DNase I Hypersensitive Site of the HER2
eu Promoter in Human Breast Cancer Cells", The Journal of Biological Chemistry 269:(31) 19848-19858, 1994.
Shindoh, et al., "Correlated Expression of Matrix Metalloproteinases and ets Family Transcription Factor EIA-F in Invasive Oral Squamous-Cell-Carcinoma-Derived Cell Lines", American Journal of Pathology 148:(3) 693-700, 1996.
Shehin-Johnson, et al., "Identification of Tissue-Specific DNase I Hypersensitive Sites in the Rabbit Flavin-Containing Monooxygenase Form 2 Gene", Drug Metabolism and Disposition 24:(8) 891-898, 1996.
Suzuki, et al., "ETS1 suppresses tumorigenicity of human colon cancer cells", Proc. Nat. Acad. Sci. USA. 92:4442-4446, 1995.
Trimble, et al., "PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas", Oncogene 8:3037-3042, 1993.
Urano, et al., "A Novel Chimera Gene between EWS and E1A-F, Encoding the Adenovirus E1A Enhancer-Binding Protein, in Extraosseous Ewing's Sarcoma", Biochemical and Biophysical Research Communications 219:608-612, 1996.
Xin, et al., Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells, Genes & Development 6:481-496, 1992.
Yoshida, et al., "Binding sites of HeLa cell nuclear proteins on the upstream region of adenovirus type 5 E1A gene", Nucleic Acids Research 17:(23) 10015-10035, 1989.
Dialog on-line search performed Jul. 15, 1996.
Mastrangelo et al. (Seminars in Oncology, vol. 23, 1996, pp. 4-21).
Erenburg et al. (Mol. Endocrinol., 1997, vol. 11, 2004-2015), (Abstract only).
Adam et al. (Cancer research, 1995, vol. 55, 5156-60.
DeNardo et al. (Proc. Natl. Acad. Sci. 1977, vol. 94, 4000-4.
Crystal R.G. (1995) Science 270: 404-409.
Marshall E. (1995) Science 269: 1050-1055.
Miller et al (1995) FASEB J. 9: 190-199.

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