Identifying sequence differences in nucleic acid populations

Details Identifying sequence differences in nucleic acid populations Identifying sequence differences in nucleic acid populations

1995-11-07

1999-07-13

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 536 243, C12Q 168, C07H 2102, C07H 2104

Patent

active

059225351

ABSTRACT:
Methods of identifying sequence differences between or among nucleic acid populations are described. Nucleic acid strands from different populations are hybridized with one another so that mismatch-containing duplexes are formed. Mismatch-containing duplexes are cleaved in a mismatch-dependent fashion and cleavage products are isolated and used to identify the genetic sequences that differ in the nucleic acid populations.

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