Method of producing a blood-coagulation-promoting preparation fr

Details Method of producing a blood-coagulation-promoting preparation fr Method of producing a blood-coagulation-promoting preparation fr

1977-08-08

1979-07-03

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3516

Patent

active

041600258

ABSTRACT:
In a method of producing a blood-coagulation-promoting preparation from human blood plasma, which preparation contains a new blood-coagulating substance called "FEIBA", human plasma with citrate ions is treated with water-insoluble inorganic coagulation-physiologically-surface-active substances in the absence of free calcium ions, thus generating "FEIBA", the water-insoluble substances are separated, the supernatant is treated with basic ion exchangers, wherein "FEIBA" and the coagulation factors II-VII-IX-X adhere to the ion exchangers, and "FEIBA" and the factors II-VII-IX-X are eluted and concentrated.

REFERENCES:
patent: 3998946 (1976-12-01), Condie et al.
patent: 4027013 (1977-05-01), Bick et al.

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