Novel thiophene-acetic acids

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424275, C07D33324, A01N 900

Patent

active

041599861

ABSTRACT:
Novel thiophene-acetic acid derivatives of the formulae ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R.sub.1 is selected from the group consisting of lower alkyl of 1 to 4 carbon atoms and hydrogen and R.sub.2 is selected from the group consisting of hydrogen, lower alkyl of 1 to 7 carbon atoms and optionally substituted with at least one hydroxy group or an oxygen atoms-containing heterocycle,di-lower alkylamino-lower alkyl, N-heterocyclic alkyl, alkali metals, alkaline earth metals, aluminum and --H,NH (lower alkyl).sub.2 and Ar is selected from the group consisting of phenyl, optionally substituted with at least one member of the group consisting of halogen, trihalogenomethyl, lower alkyl, lower alkoxy and carboxyl, cyclohexyl, thienyl, furyl, tetrahydrofuryl and pyridyl, and in formula II, ArCO is attached to one of the positions .alpha. to the sulfur atom, which compounds have analgesic and anti-inflammatory activity and their preparations.

REFERENCES:
patent: 3466372 (1969-09-01), Shen
patent: 3560525 (1971-02-01), Kaltenbronn
patent: 3577549 (1971-05-01), Jack
patent: 3644399 (1972-02-01), Brown
patent: 3682964 (1972-08-01), Rousseau

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