Uses for ascorbyl-phosphoryl-cholesterol in topical compositions

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

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424 59, 424 60, 424405, 514474, 514169, 514171, 514553, 514844, 514944, A61K 700

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059223359

ABSTRACT:
Novel uses of 3'-(L-ascorbyl-2-o-phosphoryl)-cholesterol, 3'-(L-ascorbyl-3-o-phosphoryl)-cholesterol, structural or functional isomers thereof and salts thereof (referred to collectively as "APC compounds") are disclosed. Such novel uses include a method of reducing epidermal synthesis of abnormal elastin, especially epidermal synthesis of abnormal elastin that results from exposure to UV radiation. Also disclosed is a novel method of stimulating keratinocyte formation of triglycerides. In addition, a novel method of achieving antioxidant activity, both in the skin and also in topical compositions, is disclosed.

REFERENCES:
patent: 3151127 (1964-09-01), Spanel
patent: 4254105 (1981-03-01), Fukuda
patent: 4564686 (1986-01-01), Ogata
patent: 4919921 (1990-04-01), Hatae
patent: 4939128 (1990-07-01), Kato et al.
patent: 4956355 (1990-09-01), Prendergast
patent: 4960764 (1990-10-01), Figueroa, Jr. et al.
patent: 5053222 (1991-10-01), Takasu et al.
patent: 5061733 (1991-10-01), Bryce et al.
patent: 5075333 (1991-12-01), Bryce et al.
patent: 5110950 (1992-05-01), Seib et al.
patent: 5122536 (1992-06-01), Perricone
patent: 5229378 (1993-07-01), Ogata et al.
patent: 5306713 (1994-04-01), Suetsugu et al.
patent: 5308621 (1994-05-01), Taylor et al.
patent: 5318987 (1994-06-01), Weithmann et al.
patent: 5336485 (1994-08-01), Fariss
patent: 5474991 (1995-12-01), Ogata et al.
patent: 5474992 (1995-12-01), Ogata et al.
patent: 5478815 (1995-12-01), Ogata
patent: 5480909 (1996-01-01), Sanko
patent: 5508275 (1996-04-01), Weithmann et al.
patent: 5516793 (1996-05-01), Duffy
patent: 5556842 (1996-09-01), Shimizu et al.
patent: 5574063 (1996-11-01), Perricone
patent: 5607968 (1997-03-01), Ptchelintsev
patent: 5621008 (1997-04-01), Ptchelintsev
patent: 5660976 (1997-08-01), Ishimura et al.
patent: 5683704 (1997-11-01), Ohba et al.
patent: 5703122 (1997-12-01), Duffy
Menon, et al., Structural Basis for the Barrier Abnormality Following Inhibition of HMG CoA Reductose in Murine Epidermis, J. Invest. Dermol. vol. 98, pp. 209-219 (1992).
Hans Steinhart, et al, Pro-and Antioxidative Effect of Ascobic Acid on L-Tryptophan in the System FE3+/Ascorbic Acid/02, J. Agric. Food Chem., vol. 41, pp. 2275-2277 (1993).
Sakamoto, et al., Measurement Method of Efficacy of Antidandruff Cosmetics and Development of the New Active Commerical Product, IFSCC, Yokohama, vol. B206, pp. 823-864 (1993).
Juva, Anal. Biochem., vol. 15, pp. 77-83 (1966).
Sagarin, Cosmetics, Science and Technology, 2nd Ed. vol. 1, pp. 32-43 (1972).
J. Cosmet, Cham., vol. 29, p. 185 (1978).
Szoka et al., Proc. Nat. Acad. Sciences, vol. 75, pp. 4194-4198 (1978).
Evans, Chromatographia, vol. 13, pp. 5-10 (1980).
Booth, Biochem. Biophys. Acta, vol. 675, pp. 117-122 (1981).
Mezei, J. Pharmaceut. Pharmacol., vol. 34, pp. 473-474 (1982).
Mezei, Topics in Pharmaceutical Sciences, Breimer et al. Eds., pp. 345-358, Elsevier Science Publishers BV, New York (1985).
Rainsford, Antiflammatory and Anti-Rheumatic Drugs, vol. I-III, CRC Press, Boca Raton, Florida (1985).
McCutcheon, Detergents and Emulsifiers, North American Edition, pp. 317-324 (1986).
Diploses et al., J. Soc. Cosmetics Chemists, vol. 43, pp. 93-100 (1992).

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