Substituted tetrapeptides

Details Substituted tetrapeptides Substituted tetrapeptides

1983-11-23

1986-06-17

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, 530331, C07K 702, A61K 3702

Patent

active

045956774

ABSTRACT:
Tetrapeptides of the formula I, ##STR1## in which R.sup.1 represents hydrogen or acyl, R.sup.2 represents alkyl or aralkyl, R.sup.3 represents free or functionally modified hydroxy, R.sup.4 represents free or substituted amino or free or etherified hydroxy, and -Pro-, -Phe- and -His- respectively represent the bivalent radicals of the amino acids proline, phenylalanine and histidine or the (D)-isomers thereof, salts of such compounds having salt-forming groups, and processes for their manufacture.
The compounds inhibit the action of the enzyme renin and can be used as antihypertensives and for the treatment of cardiac insufficiency.

REFERENCES:
patent: 4218474 (1980-08-01), Barnish et al.
patent: 4384994 (1983-05-01), Veber et al.
patent: 4424207 (1984-01-01), Szelke et al.
patent: 4470971 (1984-09-01), Boger et al.
patent: 4478826 (1984-10-01), Veber et al.
patent: 4479941 (1984-10-01), Veber et al.
patent: 4481192 (1984-11-01), Sanofi
patent: 4485099 (1984-11-01), Boger et al.
Chemical Abstracts, 98, 249(1983), Abst. No. 139574g.
Parsons, Peptide Hormones, U. Park Press, 1-7, (1976).
Szelke et al., Nature, vol. 299, pp. 555-557 (1982).

Affiliated with

Also associated with

Rating

Substituted tetrapeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted tetrapeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted tetrapeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2273340