Certain substituted amides having a physiological cooling effect

Drug – bio-affecting and body treating compositions – Dentifrices – Ammonia – amine – or derivative thereof

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131 17R, 131202, 252 11D, 252522, 424 45, 424 48, 424 64, 424 69, 424 70, 424 73, 424320, 426590, 426660, A61K 722

Patent

active

041361644

ABSTRACT:
Cyclic and acyclic amides, substituted ureas and sulphonamides are disclosed having the property of stimulating the cold receptors of the nervous system of the body to produce a cold sensation and are used for this purpose in a variety of edible and topical preparations.

REFERENCES:
patent: 2166119 (1939-07-01), Bosquet
patent: 3644653 (1972-02-01), Tchelitcheff
Kirk-Otmer, Encyclopedia of Chem. Tech., 2nd Ed., vol. 2, 1946, pp. 66-76.

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