Thiazole derivatives active on the cholinergic system, process f

Details Thiazole derivatives active on the cholinergic system, process f Thiazole derivatives active on the cholinergic system, process f

Filed on

1990-12-27

Date issued

1993-08-03

Examiner

Rotman, Alan L.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Heterocyclic carbon compounds containing a hetero ring...

Other Related Categories

514255, 514314, 514320, 514342, 514370, 546163, 546209, 546280, 544133, 544367, 548190, 548193, 548222, C07D27718, C07D40112, A61K 31425

Type

Patent

Status

active

Patent number

052329216

Description

ABSTRACT:
The invention relates to thiazole derivatives corresponding to the general formula: ##STR1## in which: R.sub.1 and R.sub.2 each independently represent hydrogen; a C.sub.1 -C.sub.4 alkyl group; a phenyl group or a phenyl group monosubstituted or polysubstituted by a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy, nitro or hydroxyl group; or one of the groups R.sub.1 and R.sub.2 denotes hydrogen and the other represents a naphthyl group; a benzyl group; an .alpha.,.alpha.-dimethyl-benzyl group; a cyclohexyl group; a biphenyl group; a thienyl group of an adamantyl group; or alternatively R.sub.1 and R.sub.2, taken together, represent a group; ##STR2## in which the phenyl group is bonded to the 4-position of the thiazole and the group (CH.sub.2).sub.m to the 5-position, m represents an integer equal to 2 or 3 and R.sub.5 denotes hydrogen or a nitro group, R.sub.3 is H or an alkyl group and R.sub.4 is notably an alkyl substituted by an amino group, a pyrrolidino, or a pyridino group.

REFERENCES:
patent: 4064244 (1977-12-01), Sorg
patent: 4241072 (1980-12-01), Bolhofer
patent: 4517196 (1985-05-01), Schlecker et al.
Chem. Abstracts, vol. 75(21), Abst. No. 129,703-J dated Nov. 22, 1971.

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