Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl

Details Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl

1987-12-09

1988-10-25

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 41, 530801, 426548, C07C10352, C07C10200

Patent

active

047805617

ABSTRACT:
Disclosed herein is a process for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrochloride from 5-benzyl-3,6-dioxo-2-piperazine acetic acid or its methyl ester, prepared without using L-penylalanine methyl ester which involves problems in its stability, as a raw material. Specifically, the process comprises: bringing 5-benzyl-3,6-dioxo-2-piperazine acetic acid in the presence of methanol or 5-benzyl-3,6-dioxo-2-piperazine acetic acid methyl ester in the presence or absence of methanol into contact with hydrochloric acid; isolating the thereby deposited .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride; and neutralizing said hydrochloride with an alkali as required. Preparation processes of 5-benzyl-3,6-dioxo-2-piperazine acetic acid or its methyl ester are also disclosed.

REFERENCES:
patent: 4088649 (1978-05-01), Smith et al.
patent: 4634790 (1987-01-01), Shinohara et al.

Affiliated with

Also associated with

Rating

Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2270398