Human prostatic specific reductase

Details Human prostatic specific reductase Human prostatic specific reductase

1995-06-05

1998-07-28

Sisson, Bradley L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 536 235, 935 1, 935 22, 935 66, C12N 120, C12N 1500, C07H 2104

Patent

active

057862044

ABSTRACT:
A human prostatic specific reductase polypeptide and polynucleotides encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides as a diagnostic marker for prostate cancer and as an agent to determine if the prostate cancer has metastasized. Also disclosed are antibodies specific to the prostatic specific reductase polypeptide which may be used to target prostate cancer cells and be used as part of a prostate cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.

REFERENCES:
patent: 4800159 (1989-01-01), Mullis et al.
patent: 5420245 (1995-05-01), Brown et al.
ATCC/NIH Repository Catalogue of Human and Mouse DNA Probes and Libraries, Eighth Edition, Nierman and Maglott editors, pp. 1-58, 1994.
Kleinsmith et al., Textbook 2nd Ed., "Principles of Cell and Molecular Biology" (ISBN 0-06-500404-3), p. 528 (1995).
Lewin, Textbook "Genes V" (Oxford University Press) p. 648 (1994).

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