Phthalazin-4-ylacetic acid derivatives

Details Phthalazin-4-ylacetic acid derivatives Phthalazin-4-ylacetic acid derivatives

1978-11-29

1981-02-17

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544237, 544116, C07D23730

Patent

active

042515289

ABSTRACT:
This invention relates to enzyme inhibitory, novel phthalazin-4-ylacetic acid derivatives of the general formula I: ##STR1## and pharmaceutically acceptable salts as appropriate, to pharmaceutical compositions thereof, and to analogy processes for their manufacture. The compounds of formula I are inhibitors of the enzyme aldose reductase in vivo and as such may be useful in the reduction or prevention of the development of the peripheral effects such as macular oedema, cataract, retinopathy or impaired neural conduction. A preferred compound is 2-(2-fluoro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin-4-ylacetic acid.

REFERENCES:
patent: 3864343 (1975-02-01), Inoue et al.
Jour. Khim. Farm. Zh., vol. 4, pp. 22-26 (1970).
Chem. Abstracts, vol. 73, p. 366 (77173y) 1970.

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