Methods of minimizing scattering and improving tissue sampling i

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356 39, G01J 302

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056728751

ABSTRACT:
An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed.

REFERENCES:
patent: 4555179 (1985-11-01), Langerholc et al.
patent: 4776340 (1988-10-01), Moran et al.
patent: 5028787 (1991-07-01), Rosenthal et al.
patent: 5054487 (1991-10-01), Clarke
patent: 5321265 (1994-06-01), Block
patent: 5440388 (1995-08-01), Erickson
patent: 5450193 (1995-09-01), Carlsen et al.
patent: 5522388 (1996-06-01), Ishikawa et al.
AHA Guide, ed. (American Hospital Association, Chicago, IL).
Alfano, R.R., et al, "Time-Resolved Imaging of Translucent Droplets in Highly Scattering Turbid Media," Science, vol. 264, 1913-1915 (1994).
Anderson, G.E., et al., "Microscope Imaging Through Highly Scattering Media," Optics Letters, vol. 19, No. 13, 981-983 (1994).
Andersson-Engels, S., et al., "Multispectral Tissue Characterization With Time-Resolved Detection of Diffusely Scattered White Light," Optics Letters, vol. 18, No. 20, 1697-1699; (1993).
Benaron, D., "Optical Biopsy and Imaging Advance Medical Care," Laser Focus World, 79-83 (1994).
Benaron, D. and Stevenson, D., "Optical Time-of-Flight and Absorbance Imaging of Biologic Media," Science, vol. 259, 1463-1466 (1993).
Burns, D., "Optical Tomography for Three-Dimensional Spectroscopy," Applied Spectroscopy, vol. 48, No. 5, 12A-19A (1994).
Cope, M. and Delpy, D.T., "System for Long-term Measurement of Cerebral Blood and Tissue Oxygenation on Newborn Infants by Near Infra-red Transillumination," Medical & Biological Engineering & Computing, 289-294 (1988).
Cope, M. et al., "Data Analysis Methods for Near Infrared Spectroscopy of Tissue: Problems in Determining the Relative Cytochrome aa.sub.3 Concentration," SPIE, vol. 1431, 251-261 (1991).
Cope et al., "Methods of Quantitating Cerebral Near Infrared Spectroscopy Data," Adv. Exp. Med. Biol., vol. 222, 183-190 (1988).
Das, B.B., et al., "Ultrafast Time-gated Imaging in Thick Tissues: a Step Toward Optical Mammography," Optics Letters, vol. 18, No. 13, 1092-1094 (1993).
de Kock, J.P., and Tarassenko, L., "Pulse Oximetry: Theoretical and Experimental Models," Med. Biol. Eng. Comp., vol. 31, 291-300 (1993).
Delpy, D.T., et al., "Estimation of Optical Pathlength Through Tissue From Direct Time of Flight Measurement," Phys. Med. Biol., vol. 33, No. 12, 1433-1442 (1988).
Diem and Lentner (eds.), Scientific Tables: Documenta Geigy, 7th ed., 1970 (J. R. Geigy, Basle).
Fine, I., and Weinreb, A., "Multiple-scattering Effects in Transmission Oximetry," Med. Biol. Eng. Comp., vol. 31, 516-522 (1993).
Kohl, M., and Cope, M., "Influence of Glucose Concentration on Light Scattering in Tissue-simulating Phantoms," Optics Letters, vol. 19, No. 24, 2170-2172 (1994).
Kubelka, P., "New Contributions to the Optics of Intensely Light-Scattering Materials. Part II: Nonhomogeneous Layers," J. Opt. Soc. America, vol. 44, 330-335 (1954).
Maier, J., et al., "Possible Correlation Between Blood Glucose Concentration and the Reduced Scattering Coefficient of Tissues in the Near Infrared," Optics Letters, vol. 19, No. 24, 2062-2064 (1994).
Mendelson, Y., "Pulse Oximetry: Theory and Applications for Noninvasive Monitoring," Clin. Chem., vol. 38, No. 9, 1601-1607 (1992).
Sanchez-Carrillo, C., et al., "Test of a Noninvasive Instrument for Measuring Hemoglobin Concentration," Intl. J. Technol. Assess. Health Care, vol. 5, No. 4, 659-666 (1989).
Schmitt, J., "Simple Photon Diffusion Analysis of the Effects of Multiple Scattering on Pulse Oximetry," IEEE Trans. Biomed. Eng., vol. 38, No. 12, 1194-1203 (1991).
Schmitt, J., et al., "Measurement of Blood Hematocrit by Dual-wavelength Near-IR Photoplethysmography," SPIE, vol. 1641, 150-161 (1992).
Sodickson, L., and Block, M., "Kromoscopic Analysis: A Possible Alternative to Spectroscopic Analysis for Noninvasive Measurement of Analytes In Vivo," Clin. Chem., vol. 40, No. 9, 1838-1844 (1994).
Steuer, R.R., et al., "Clinical Evaluation of the Noninvasive Hematocrit Monitor," Am Clin. Lab., vol. 11, No. 5, 18-21 (1992).
Steuer, R.R., et al., "Evaluation of a Noninvasive Hematocrit Monitor: A New Technology," Am. Clin. Lab., vol. 10, No. 6, 20-22 (1991).
Wist, A., et al., "Increased Spatial Resolution in Transillumination Using Collimated Light," IEEE Transactions on Medical Imaging, vol. 12, No. 4, 751-757 (1993).
Wukitsch, M., et al., "Pulse Oximetry: Analysis of Theory, Technology, and Practice," J. Clin. Monit., vol. 4, No. 4, 290-301 (1988).
Wyatt, J.S. et al., "Measurement of Optical Path Length for Cerebral Near-Infrared Spectroscopy in Newborn Infants," Dev. Neurosci., vol. 12, 140-144 (1990).

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