Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1989-10-16
1992-03-31
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Lymphokine
424 89, 424 92, 424450, 4284022, A61K 9127, A61K 9133, A61K 3939, A61K 39385
Patent
active
051006626
ABSTRACT:
The present invention relates to novel liposomes and liposome-like structures (vesicles) comprising an amount of a derivatized sterol either alone or in combination with additional liposome-forming lipids.
Sterols such as cholesterol or other lipids, to which numerous charged or neutral groups are attached, may be used to prepare liposomes and liposome-like structures such as micelles, reverse micelles and hexagonal phases, suspensions of multilamellar vesicles or small unilamellar vesicles. The novel liposomes of the present invention may be prepared with or without the use of organic solvents. These vesicles may entrap compounds varying in polarity and solubility in water and other solvents. The vesicles of the present invention may function as vaccines after entrapment or association of an immunogen, as adjuvants, either alone or in combination with additional adjuvants, including, for example, Freund's adjuvant (and other oil emulsions), Bortedella Pertussis, aluminum salts and other metal salts and Mycobacterial products (including muramyldipeptides), among others. The present invention relates to novel liposomes and liposome-like structures (vesicles) comprising an amount of a derivatized sterol either alone or in combination with additional liposome-forming lipids.
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Bolcsak Lois E.
Boni Lawrence
Popescu Mircea C.
Tremblay Paul A.
Bloom Allen
Covert John M.
Lovering Richard D.
Ort Ronald G.
The Liposome Company Inc.
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