Biocompatability for solid surfaces

Details Biocompatability for solid surfaces Biocompatability for solid surfaces

1995-08-22

1997-09-30

Merriam, Andrew E. C.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Processes of preparing a desired or intentional composition...

523113, 424423, 424 7836, 435180, 435181, 427 225, 623 1, A61F 202, C12N 1108

Patent

active

056726384

ABSTRACT:
An improved coating and spacer material for a medical device having a blood or tissue-contacting surface comprising a polyalkyleneimine layer which is crosslinked with a crosslinking agent which is at least difunctional in polymerizable vinyl groups which have adjacent strong electron-withdrawing groups and a biomolecule covalently bonded to the crosslinked polyalkyleneimine layer. For example, polyethyleneimine crosslinked with divinyl sulfone could be used. The resulting crosslinked spacer layer has improved uniformity and stability without materially limiting the covalent attachment of a biomolecule such as heparin.

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