Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-06-18
1997-09-30
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 17, 530330, 530331, 530333, A61K 3804, A61K 3807, C07K 500
Patent
active
056725868
ABSTRACT:
Disclosed herein are compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or (1-4C) alkyl, R.sup.2 is (1-4C) alkyl or a therapeutically acceptable salt thereof. The compounds are useful for treating herpes infections.
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patent: 4814432 (1989-03-01), Freidinger et al.
patent: 5574015 (1996-11-01), Beaulieu et al.
R.E. Boehme et al., Chapter 15, Antiviral Agents in "Annual Reports in Medicinal Chemistry", 29, pp. 145-154 (1994).
P. Gaudreau et al., "Synthesis and Inhibitory Potency of Peptides Corresponding to the Subunit 2 C-Terminal Region of Herpes Virus Ribonucleotide Reductases", J. Med. Chem., pp. 723-730 (1990).
L.L. Chang et al. "Substituted Penta-and Hexapeptides as Potent Inhibitors of Herpes Simplex Virus Type 2 Ribonucleotide Reductase", Bioorganic and Medicinal Chemistry Letters, pp. 1207-1212 (1992).
N. Moss et al., "Inhibition of Herpes Simplex Virus Type 1 Ribonucleotide Reductase by Substituted Tetrapeptide Derivatives", J. Med. Chem., pp. 3005-3009 (1993).
Gauthier Jean Andre
Moss Neil
Bio-Mega Boehringer Ingelheim Research Inc.
Celsa Bennett
Raymond Robert P.
Rieder Wendy E.
Stempel Alan R.
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