Human SMN-like protein

Details Human SMN-like protein Human SMN-like protein

1998-02-24

2000-10-10

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 235, 4353201, 435225, 4352523, C12N 1512

Patent

active

061300640

ABSTRACT:
The invention provides a human SMN-like protein (HSLP) and polynucleotides which identify and encode HSLP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HSLP.

REFERENCES:
Lefebvre, S., et al., "Identification and Characterization of a Spinal Muscular Atrophy-Determining Gene," Cell, 80:155-165 (1995).
Burglen, L., et al., "Structure and Organization of the Human Survival Motor Neurone (SMN) Gene," Genomics, 32:479-482 (1996).
Coovert, D., et al., "The survival motor neuron protein in spinal muscular atrophy," Human Molecular Genetics, 6(8):1205-1214 (1997).
Liu, Q. And Dreyfuss, G., "A Novel nuclear structure containing the survival of motor neurons protein," The Embo Journal, 15(14):3555-3565 (1996).
Viollet, L., et al., "cDNA Isolation, Expression, and Chromosomal Localization of the Mouse Survival Motor Neuron Gene (Smn)," Genomics, 40:185-188 (1997) (GI 1857114 & GI 1857113).
Schrank, B., et al., "Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos," Proc. Natl. Acad. Sci., 94:9920-9925 (1997).
Viollet, L., et al., (GI 1857114), GenBank Sequence Database (Accession U63294), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Violett, L., et al., (GI 1857113), GenBank Sequence Database (Accession U63294), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Burglen, L., et al., (GI 1314346), GenBank Sequence Database (Accession U43876), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Burglen, L., et al., (GI 1314337), GenBank Sequence Database (Accession U43876), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
EMBL/GenBank Databases Accession No. Z78358 Sequence reference HSZ78358 Aug. 16, 1996, Neri, C. et al: "Survey of CAG/CTG repeats in human cDNAs representing new genes: candidates for inherited neurological diseases", XP002106944.
Neri, C. et al., "Survey of CAG/CTG repeats in human cDNAs representing new genes: candidates for inherited neurological disorders", Human Molecular Genetics, vol. 5, No. 7, Jul. 1, 1996, pp. 1001-1009, XP000673216.
EMBL/GenBank Databases Accession No. T91668 Sequence reference HS66857, Apr. 11, 1995, Hillier, L. et al: "The WashU-Merck EST Project", XP002106945.
Neubauer, G. et al., "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex", Nature Genetics, vol. 20, Sep. 1998, pp. 46-50, XP002106943.
EMBL-GenBank Databases Accession No. AF083385 Sequence reference AF083385, Oct. 16, 1998, Neubauer, G. et al: "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex", XP002106946.
EMBL/GenBank Databases Accession No. AF107463 Sequence reference AF107463, Dec. 11, 1998, Chen, J. et al: "Isolating and cloning HSP cDNA", XP002106947.
EMBL/GenBank Databases Accession No. AI182770 Sequence reference AI182770, Oct. 13, 1998, Marra, M. et al: "The WashU-HHMI Mouse EST project", XP002106948.
Genbank Accession No. N22328, Dec. 1995.
Genbank Accession No. AA180296, Dec. 1996.

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