Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1998-03-03
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544280, C07D48704, A61K 31505
Patent
active
057234663
ABSTRACT:
This invention relates to Trans cyclopentanyl purine analogs of the formula (1) ##STR1## wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent,
REFERENCES:
patent: 3682918 (1972-08-01), Druey et al.
patent: 3917837 (1975-11-01), Lin et al.
patent: 4038479 (1977-07-01), Elion et al.
patent: 4076711 (1978-02-01), Ganguly et al.
patent: 4386093 (1983-05-01), Chiang et al.
patent: 4742064 (1988-05-01), Vince et al.
patent: 4854215 (1989-08-01), Shimada et al.
patent: 4859677 (1989-08-01), Borchardt et al.
patent: 4916224 (1990-04-01), Vince et al.
patent: 4954504 (1990-09-01), Chen et al.
patent: 5039689 (1991-08-01), Daluge
patent: 5126452 (1992-06-01), Vince et al.
patent: 5244896 (1993-09-01), Borcherding et al.
Trost, et al., A Transition-Metal-Controlled Synthesis of (.+-.) Aristeromycin and (.+-.)2',3'-diepi-Aristeromycin. An Unusual Directive Effect in Hydroxylations, J. Am. Chem. Soc. vol. 110, 621-622, (1988).
Hasobe, et al., 9(Trans-2'Trans 3'-Dihydroxyclopentanyl)-Adenine and 3-Deazaadenine Analogues of Aristeromycin Which Exhibit Potent Antiviral Activity with Reduced Cytotoxicity. FASEB Journal vol. 4, A1771 (Abstr. #455) (1990).
Ault-Riche, et al., Effects of 4'-Modified Analogs of Aristeromycin and Neplanocin A on Metabolism of S-Adenosyl-L-Homocysteine in Mouse L929 Cells, FASEB Journal vol. 4, A2050 (Abstr. #2064) (1990).
Wolf, et al., 4'Modified Analogs of Aristeromycin and Neplacin A: Synthesis and Adenosyl-Homocysteine Hydrolase Inhibitory Activity 199th ACS National Meeting, Boston, Mass., Apr. 1990, Abstrct #27.
Koga, et al., The Synthesis of two 2'Deoxy Carbocyclic Purine Nucleosides Lacking the 5'Methylene, Tetrahedron Letters, vol. 31, 5861, (1990).
Schaffer, et al., Synthesis of Potential Anticancer Agents. XXV Preparation of Some Cis and Trans-2-(6-Substituted 9-Purinyl)cyclopentanols, J. of Org. Chem. vol. 25, 771-776, (1960).
Kahan I, Curr. Opin. Immunology 4, 553 (1992).
Kahan II Immunological Reviews #136, p. 29 (1993).
Borcherding David R.
Cole Douglas L.
Edwards III Carl K.
Esser Ronald E.
Hoechst Marion Roussel Inc.
Payne T. Helen
Rao Deepak R.
Shah Mukund J.
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