Starting materials in the synthesis of thrombin and kinogenase i

Details Starting materials in the synthesis of thrombin and kinogenase i Starting materials in the synthesis of thrombin and kinogenase i

1995-06-06

1998-03-03

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

564244, 564225, 564182, A61K 3800, C07C25700, C07C23300, C07C23500

Patent

active

057234442

ABSTRACT:
The invention concerns the compounds of the formulas: ##STR1## and protected forms and salts thereof which serve as starting materials in an improved method of synthesizing thrombin and kininogenase inhibitors. The invention further concerns an improved method for synthesizing the inhibitors which utilizes the compounds.

REFERENCES:
patent: 4346078 (1982-08-01), Bajusz et al.
patent: 4568636 (1986-02-01), Svendsen
patent: 4703036 (1987-10-01), Bajsuz et al.
patent: 4977168 (1990-12-01), Bernat et al.
patent: 5037819 (1991-08-01), Han
patent: 5110812 (1992-05-01), Han
patent: 5187157 (1993-02-01), Kettner et al.
patent: 5260307 (1993-11-01), Ackermann et al.
Jackson et al. "Pharmacological Assessment of the Antithrombotic Activity of the Peptide Thrombin Inhibitor. . .", J. of Pharm. Exp. Ther. 261: 546-552, 1992.
Knabb et al. "In Vivo Characterization of a new Synthetic Thrombin Inhibitor", Thrombosis and Haemostasis, 67 (1) : 56-59, 1992.
Bajusz et al. "Inhibition of Thrombin with H- and Boc-D-Phe-Pro-Agm, " Chem. Abs. 99: 205609w, 1983.
Klement et al. "The Effect of Thrombin Inhibitors on Tissue Plasminogen Activator induced Thrombolysis in a Rat Model", Thrombosis and Haemostasis, 68 (1) : 64-68, 1992.
Marki et al., "The Anticoagulant and Antithrombotic Properties of Hirudins", Thrombosis and Haemostasis, 64 (3): 344-348, 1990.
Broersma et al., "The Effect of Thrombin Inhibition in a Rat Arterial Thrombosis Model", Thrombosis Research, 64: 405-412, 1991.
Persson et al. Throax 47: 993-1000, 1992.
Salomonson et al. Am. Rev. Resp. Dis. 146: 1535-1542, 1992.
Markwardt et al. Biochem. Pharm. 23: 2247-2256, 1974.
Malek et al. "Palladium-catalyzed synthesis of Cinnamylamides", J. Org. Chem. 47 (27) : 5395-5397, 1982.
Malek et al. Chem. Abs. 98: 16353, 1983.
Chung et al. J. Organic Chem. 1: 270-275.
Glusa et al. "The influence of benzamidine derivaties on human platelet function," Thrombosis et Diathesis Haemorrhagica 31: 172-178, 1974.
Anderson and Lok, J. Organic Chem. 37: 3953, 1972.
Fareed et al., Ann. N.Y. Acad. Sci. 370: 765-784, 1981.
Geratz, J.D. "Inhibition of thrombin, plasmin and plasminogen compounds," Thrombosis et Diathesis Halmorrhagica 23(3), 486-499, 1970.

Affiliated with

Also associated with

Rating

Starting materials in the synthesis of thrombin and kinogenase i does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Starting materials in the synthesis of thrombin and kinogenase i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Starting materials in the synthesis of thrombin and kinogenase i will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2247737