Method for treating neurogenic red skin blotches with compositio

Details Method for treating neurogenic red skin blotches with compositio Method for treating neurogenic red skin blotches with compositio

1996-11-20

1999-04-20

Naff, David M.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

4241951, 424520, 514 2, 514263, 514338, 514557, 514588, 514738, 514886, 514887, 514937, 514938, A61K 39395, A61K 3512, A61K 3578, A61K 3118

Patent

active

058956492

ABSTRACT:
Topically applicable pharmaceutical/dermatological/cosmetic compositions, well suited for the therapeutic treatment of neurogenic red skin blotches and rosacea afflicting the skin, scalp and/or mucosae of a human subject, comprise a therapeutically/cosmetically effective amount of at least one TNF-alpha antagonist.

REFERENCES:
Gallin, In Fundamental Immunology, Third Edition, Ed., W.E. Paul, Raven Press, Ltd., NY, pp. 1015-1032, 1993.
J. Invest. Dermatol., vol. 102, No. 6, 1994, pp. 934-937, XP000576630, G. Senaldi et al.: "Protective effect of N-acetylcysteine in hapten-induced irritant and contact hypersensitivity reactions".
J. Exp. Med., vol. 173, No. 3, 1991, pp. 673-679, XP000576859, P.F. Piguet et al.; "Tumor necrosis factor is a critical mediator in hapte-induced irritant and contact hypersensitivity reactions".
Agents & Actions, vol. 38, No. s.i. II, 1993, pp. C212-C214, XP000576409, N.A. Hayes et al.: "The action of a calcitonin gene-related peptide antagonist in human skin".
Semin. Dermatol., vol. 10, No. 3, 1991, pp. 138-147, XP000576399, J.T. APGAR: "Newer aspects of inflammatory bowel disease and its cutaneous manifestations: a selective review".
Cell. Immunol., vol. 161, No. 2, 1995, pp. 288-294, XP000576633, N. Higashi et al; "Involvement of inflammatory cytokines in a delayed-type hypersensitivity reaction".

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