Cell-specific glycopeptide ligands

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 53, 536 187, 536 54, 536115, C07C10352, C08B 3700, C07H 1100

Patent

active

043860265

ABSTRACT:
Cell-specific ligands comprising conjugates of saccharides and amino acids or peptides are synthesized from amino acids such as ornithine, lysine, peptides such as dilysine, diornithine or oligolysine and selected saccharides having reactive functional groups protected by appropriate blocking groups. Such glycopeptides are useful as tissue specific substances, which when coupled with bioactive materials through metabolizable or hydrolyzable linkages, deliver such bioactive materials to the selected site. In this manner, antiinflammatory drugs such as dexamethasone are linked through a metabolizable or hydrolyzable linkage and on administration to an animal suffering from inflammatory disease carries the drug to the site of inflammation for intracellular release. Other examples include the macrophage ligand N.sup.2 -N.sup.2, N.sup.6 -Bis-[3-(.alpha.-D-mannopyranosylthio)propionyl]-6-lysyl-N.sup.6 -[3-(.alpha.-D-mannopyranosylthio)propionyl]-L-lysine, 5, which when coupled to .beta.-glucocerebrosidase, can deliver the enzyme selectively to kupffer cells. This is useful in the enzyme replacement therapy of Gaucher's disease.

REFERENCES:
patent: 3226379 (1965-12-01), Steyermark et al.
patent: 3859337 (1975-01-01), Herz et al.
patent: 4120953 (1978-10-01), Nair et al.
patent: 4175073 (1979-11-01), Carlsson et al.
patent: 4195128 (1980-03-01), Hildebrand et al.
patent: 4223013 (1980-09-01), Hu et al.
patent: 4241053 (1980-12-01), Tsujihara
patent: 4259233 (1981-03-01), Carrico et al.
Biol. Abstr. 68, 24673.
Biol. Abstr. 67, 27708.
Biol. Abstr. 69, 34308.
Chabala et al., Carbohydrate Research, 67, (1978), pp. 55-63.
Ponpipom et al., Canadian Journal of Chemistry, 58, pp. 214-220 (1980).
Mauk et al., Science, 207, pp. 309-311 (1980).
Mauk et al., Proc. Natl. Acad. Sci. U.S.A., 77, pp. 4430-4434 (1980).
Martodam et al., Proc. Natl. Acad. Sci. U.S.A., 76, pp. 2128-2132 (1979).
Ashwell et al., Adv. Enzmol., 41, pp. 99-129 (1974).
Gregoriadis, G., Nature, 265, pp. 407-411 (1977).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cell-specific glycopeptide ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cell-specific glycopeptide ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cell-specific glycopeptide ligands will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2245522

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.