Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing
Patent
1995-06-01
1998-03-03
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
424 9464, 435216, 435217, 435219, A61K 3843, A61K 3848, C12N 948, C12N 970
Patent
active
057231222
ABSTRACT:
The invention relates to the use of thromboembolic proteins. These contain, as their only structural portion effecting thrombolytic activity, the protease domain of human tissue type plasminogen activator. These derivatives show reduced side effects, such as a reduction in bleeding while. demonstrating remarkable in vivo efficacy. The effect is surprising, given their in vitro properties.
REFERENCES:
patent: 5223256 (1993-06-01), Stern et al.
patent: 5242688 (1993-09-01), Burck et al.
Burck et al., "Characterization of a Modified Human Tissue-Plasminogen Activator Comprising a Kringe-2 and a Protease Domain", J. Biol. Chem. 265 (9): 5170-5177 (1990).
Robinson et al., "Redesigning t-PA for improved thrombolytic-therapy", Trends Biotech. 9 (3): 86-90 (1991).
Gething et la., "Variants of Human Tissue Type Plasminogen-Activator That Lack Specific Structural Domains of the Heavy Chain", EMBO J 7(9): 2731-2740 (1988).
Stockinger et al., 1992, Thrombosis Res., vol. 67, pp. 589-599.
Konnert et al., 1992, Protein Eng., vol. 5, No. 1, pp. 93-100.
Fischer Stephan
Kohnert Ulrich
Martin Ulrich
Stern Anne
Boehringer Mannheim GmbH
Knode Marian C.
Salimi Ali R.
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