Steroid 5-alpha-reductase inhibitors

Details Steroid 5-alpha-reductase inhibitors Steroid 5-alpha-reductase inhibitors

1992-02-04

1993-08-17

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 63, 544 96, 544125, 544361, 544335, 544224, 546 77, C07J 7500, C07J 7300

Patent

active

052370658

ABSTRACT:
Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-alpha-reductase.

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Blohm, Biochem. and Biophys. Research Commun. 95(1), 1980 pp. 273-280.
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Imperato-McGinley J. Steroid Biochem. 11 637-645, 1979.
Robaire et al. J. Steroid Biochem. 1977 (8) 307-310.
Llang et al. J. Steroid Biochem. 19(1) 385-390, 1983.

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