Liquid purification or separation – Processes – Separating
Patent
1996-01-03
1998-03-03
Reifsnyder, David A.
Liquid purification or separation
Processes
Separating
210782, 210787, 2103601, 2103801, 422 72, 422101, 494 27, 494 34, 494 45, 604410, B01D 2126
Patent
active
057230501
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to a bag-set intended for batch centrifugal separation. More particularly, the present invention relates to a bag-set of the type which comprises an essentially ring-shaped outer bag and an inner bag, formed from the central part of the ring, as well as one or more connecting channels between the interiors of these bags.
BACKGROUND OF THE INVENTION
Systems of coupled bags have been used for the centrifugal separation of blood, blood products and other biological fluids. In these systems, the fluid which is to be separated is supplied to a primary bag of the system and after centrifugation and separation of the fluid into two or more fractions, one or more of these fractions is pressed into the attached or secondary bags. For use in centrifugal separation, specially adapted round and ring-shaped or annular bags are known in this connection. Bag systems of this type are described e.g. in U.S. Pat. Nos. 4,990,132 and 5,114,396. These documents also disclose how this type of bag-system can be manufactured from plastic films which are superimposed on one another and joined by means of an outer ring-shaped seam and an inner ring-shaped seam, so that a ring-shaped or annular outer bag is formed as well as a plate-shaped or circular inner bag in the central portion of the ring. It is also possible for several chambers to be arranged, one upon the other, in the inner bag, depending on the number of film layers which are sealed together. The inner seam is suitably provided with perforations so that the outer and inner bags can be separated from each other.
The fluid which is to be separated can thus be supplied to the outer ring-shaped bag and after centrifugation is subjected to an external pressure which presses the fraction which is closest to the center of the rotor, through the connecting channel, to the inner bag. Several different combinations of connected channels can be employed if the inner bag comprises a plurality of chambers. Different methods are also known for achieving the compressive pressure on the bag while it is in the rotor and undergoing rotation.
From a point of view of cost it is advantageous if the inner bag can be manufactured from film material which is obtained from the remaining central portion of the outer bag. If a large volume is required for the inner bag, this means, however, that the diameter of the outer bag will be large, which is a disadvantage with many applications and requires centrifuges with large rotor diameters.
It is therefore an object of the present invention to provide an improved bag-system of the aforementioned type which provides increased flexibility as regards the choice of the volume of the inner bag and the diameter of the outer bag.
This and other objects and advantages which are described in more detail in the following description, are achieved by a bag-system hereof.
SUMMARY OF THE INVENTION
In accordance with the present invention, these and other objects have now been accomplished by the invention of centrifugal separation apparatus, primarily for the separation of biological fluids, comprising an inner circular bag portion having an outer diameter, an outer annular bag portion having an inner diameter corresponding to the outer diameter of the inner circular bag portion, a connecting channel for providing fluid communication between the inner circular bag portion and the outer annular bag portion, and central mounting means comprising a rigid circular mounting member for mounting the outer annular bag portion for centrifugation in a manner such that the outer annular bag portion adopts a conical configuration by shortening the inner diameter of the outer annular bag portion.
In a preferred embodiment, the inner circular bag portion and the outer annular bag portion are detachably formed from integral bag forming material. In a preferred embodiment, the apparatus includes a plurality of connecting channels.
In accordance with another embodiment of the centrifugal separation apparatus of the prese
REFERENCES:
patent: 3724747 (1973-04-01), Unger et al.
patent: 3858796 (1975-01-01), Unger et al.
patent: 3987961 (1976-10-01), Sinn et al.
patent: 4230263 (1980-10-01), Westberg
patent: 4990132 (1991-02-01), Unger et al.
patent: 5114396 (1992-05-01), Unger et al.
Unger Peter
Westberg Eric
Omega Medicinteknik AB
Reifsnyder David A.
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