Anti-fungal agent

Details Anti-fungal agent Anti-fungal agent

1992-04-10

1993-08-17

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514546, A01N 3700, A01N 3702, A61K 3119, A61K 3122

Patent

active

052369552

ABSTRACT:
A method is disclosed for producing a selective fungicidal effect upon Cryptococcus neoformans by treatment of said organism or a mammalian host infected with said organism with a small but effective amount of 4-oxatetradecanoic acid.

REFERENCES:
patent: 5073571 (1991-12-01), Heuckeroth et al.
patent: 5082967 (1992-01-01), Heuckeroth et al.
Gershon et al., J. Pharmaceut. Sci. 68, 86-84 (1979).
Schneirson's Atlas of Diagnostic Microbiol., Abbott Labs., 8th ed. 1982, pp. 48 and 50.
Bryant et al., Proc. Natl. Acad. Sci. USA 86, 8655-8659 (1989).
Bryant et al., Proc. Natl. Acad. Sci. USA 88, 2055-2059 (1991).
Devadas et al, J. Biol. Chem. 267, 7224-7239 (1992).
Johnson et al, Proc. Nat'l Acad. Sci. USA 87, 8511-8515 (1990).

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