Microbiological oxidation of methyl groups in heterocycles

Details Microbiological oxidation of methyl groups in heterocycles Microbiological oxidation of methyl groups in heterocycles

1991-10-30

1993-08-17

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435118, 435119, 435120, 435121, 435122, 435123, 435124, 435125, 435126, 4352533, 435877, C12P 1700, C12P 1710, C12P 1704, C12R 140

Patent

active

052368327

ABSTRACT:
A microbiological process for the oxidation of methyl groups in aromatic 5- or 6-member ring heterocycles to the corresponding carboxylic acid. The heterocycle serves as the substrate and exhibits no substituent on the carbon atoms adjacent to the methyl groups to be oxidized. The reaction of the heterocycle takes place by means of microorganisms of the genus Pseudomonas utilizing toluene, xylene, or cymene. The enzymes of the microorganisms been previously induced.

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