Novel nitrosourea compounds and process for preparing the same

Details Novel nitrosourea compounds and process for preparing the same Novel nitrosourea compounds and process for preparing the same

1979-08-14

1980-12-23

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 18, 536 22, 536 53, A61K 3170, A61K 3173, C07H 1312

Patent

active

042410533

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sup.1 is lower alkoxy, lower alkoxy-methoxy or 2-hydroxy-ethoxy, R.sup.2 is aldo-pentofuranosyl, aldo-pentopyranosyl, aldohexopyranosyl or O-aldo-hexopyranosyl-(1.fwdarw.4)-aldo-hexopyranosyl, and A is straight or branched alkylene of one to four carbon atoms, said alkylene being substituted with from 0 to at least one lower alkoxy group, is disclosed. A new intermediate used in the preparation of this compound is also disclosed. The end products are useful for inhibiting the growth of malignant tumor cells in warm-blooded animals; especially Leukemia and Ejrlich ascites carcinoma. Effectiveness on human beings has not yet been demonstrated.

REFERENCES:
patent: 3577406 (1971-05-01), Hessler
patent: 4086415 (1978-04-01), Suami et al.
patent: 4156777 (1979-05-01), Kimura
patent: 4157439 (1979-06-01), Suami et al.

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