Hematoporphyrin derivative and method of preparation and purific

Details Hematoporphyrin derivative and method of preparation and purific Hematoporphyrin derivative and method of preparation and purific

1986-11-26

1989-08-29

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48722

Patent

active

048618764

ABSTRACT:
A substance effective for treatment of tumors having a fluorescent emission between 640 nm and 650 nm capable of preferentially localizing in and being retained in tumor cells, the substance being a product of esterification of hematorporphyrin with a chlorin and a process for destruction of tumor cells in a patient involving the steps of:

REFERENCES:
patent: 4649151 (1987-03-01), Dougherty
"Current Topics Porphyrin Phototherapy of Human Cancer"; E. J. Land, pp. 219-223, 1984.
"Hematoporphyria & HPD: Photophysics, Photochemistry and Phototherapy"; Photochemistry and Photobiology vol. 39 No. 6 1984 pp. 851-859.
"Porphyrin Localization and Treatment of Tumors"; Liss 1984 pp. 75-87.
"Biological and Biophysical Properties of the Tumor Localizing Component of Hematoporphyrin Derivative"; David Kessel, May-Ling Cheng Jul., 1985 pp. 3053-3057.
"Determinants of Hematoporphyrin-Catalyzed Photosensitization"; David Kessel, Mar. 1, 1982 pp. 99-101.
"Photodynamic Effects: Porphyrin vs Chlorin"; David Kessel and Christopher J. Dutton; Apr. 3, 1984 pp. 403-405.
"Hematoporphyrin Derivative and Photoradiation Therapy in Early Stage Lung Cancer"; Yoshihiro Hayata et al., pp. 37-47 1984.
"Photophysics of and Instrumentation for Porphyrin Detection and Activation" Daniel Doiron pp. 41-73, 1984.
"Light Dosimetry in Tissue: Application to Photoradiation Therapy"; Daniel R. Doiran, Lars O. Svaasandt and Edward Profio pp. 63-76.
"Porphyrin Derivative: A New Aid for Endoscopic Detection of Malignant Disease"; Lipson et al., pp. 623-629 1961.

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