Hydantoin derivatives for treating complications of diabetes

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514253, 514278, 514382, 5142335, 544 70, 544230, 546 15, 548253, 548309, A61K 31415, C07D491107

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active

048617920

ABSTRACT:
Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group,

REFERENCES:
patent: 4740517 (1988-04-01), Kurono et al.
Kinoshita, J. H. et al., Jap.J.Ophthalmol., vol. 20, 339-410, 1976.
Kenneth H. Gabbay, Int. Congr. Ser. Excerpta Med., vol. 403, p. 594, 1977.
Peterson, M. J. et al., Metabolism, vol. 28, p. 456, 1979.
Ziegler, E., et al., Liebigs Ann. Chem., pp. 1552-1556, 1973.
Witiak, D. T. et al., J. Med. Chem., vol. 14, No. 8, 758-756 (1971).

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