Certain transient pro-drug forms of phenylbutazone

Details Certain transient pro-drug forms of phenylbutazone Certain transient pro-drug forms of phenylbutazone

1975-01-06

1976-05-18

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602955A, 260310A, 424263, 424273, C07D21381

Patent

active

039578038

ABSTRACT:
Transient, pro-drug forms of phenylbutazone and oxyphenbutazone, which are 1,2-diphenyl-4-butyl-5-oxy-4-pyrazolin-3-one derivatives, are disclosed.
These compounds exhibit anti-inflammatory activity in warm-blooded animals. Upon administration to warm-blooded animals, these compounds pass through the gastrointestinal tract and "cleave" in the bloodstream, thus releasing phenylbutazone or oxyphenbutazone in an anti-inflammatory effective amount at their therapeutic site or sites of activity.

REFERENCES:
burger, Medicinal Chemistry, Third Edition, Part 2, Wiley-Interscience Pub. pp. 958-960, (1970).

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