Oxazoles and thiazoles containing an aminohydroxypropoxyphenyl m

Details Oxazoles and thiazoles containing an aminohydroxypropoxyphenyl m Oxazoles and thiazoles containing an aminohydroxypropoxyphenyl m

1985-11-05

1988-04-05

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514374, 548205, 548235, C07D26332, C07D27728, A61K 3142, A61K 31425

Patent

active

047359617

ABSTRACT:
Novel substituted aminohydroxypropoxyphenyl oxazole and thiazole compounds and methods for their preparation are disclosed. These compounds, and their salts exhibit cardioselective .beta.-adrenergic blocking activity, and are useful as antihypertensive, cardioprotective, antiarrhythmic and antianginal agents.

REFERENCES:
patent: 3328417 (1967-06-01), McLoughlin et al.
patent: 4134983 (1979-01-01), Baldwin
patent: 4440774 (1984-04-01), Baldwin
patent: 4559354 (1985-12-01), Fuhrer et al.
patent: 4574127 (1986-03-01), Baldwin et al.
Crowther et al., J. Med. Chem., vol. 15, No. 3, pp. 260-266, (1972).

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