Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-subst

Details Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-subst Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-subst

1986-12-22

1988-04-05

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514314, 514414, 514422, 544333, 546167, 546281, 548466, 548527, A61K 31395, A61K 3144, C07D40514

Patent

active

047359587

ABSTRACT:
Certain trans-6-[2-[2-(substituted-phenyl)-3- (or 4-)heteroaryl-5-substituted-1H-pyrrol-1-yl]ethyl]tetrahydro-4-hydroxy-2H-p yran-2-ones and the corresponding lactone-ring-opened acids are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase) and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.

REFERENCES:
patent: 4613610 (1986-09-01), Wareing
patent: 4647576 (1987-03-01), Hoefle et al.

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